Magnesium and Acne – Why Your Skin Needs More Magnesium

Magnesium can help many of the underlying causes of acne.

Magnesium can help many of the underlying causes of acne.

Sad fact: if you’re reading this and you’re human, you’re probably magnesium deficient.

(If you’re reading this and not human, you’re probably an alien with nutrient vats with squiggling life forms in them. Erm… you might be fine.)

For the rest of us sentient beings the magnesium situation is grim: anywhere from 50% to 80% percent of us are not even getting the RDA.[1] Even those who are getting RDA are getting barely enough to sustain the body’s baseline chemical reactions.[2] [3]

Not good.

This isn’t one of those optional minerals that’s just “nice” or “beneficial.”

You need magnesium. Your body uses it for more than three hundred different enzymatic reactions. You can’t synthesize proteins without it. Your nervous system can’t pass signals without it. Your blood glucose levels would be wildly out of control. Your bones wouldn’t develop properly.

Without magnesium your muscles wouldn’t be able to contract and relax – including a somewhat useful muscle you might have heard of… your heart.

Without magnesium you couldn’t even produce the energy to get up and move. Magnesium ions are critical to the production of adenosine triphosphate (ATP), the basic unit of energy in our cells.

Even plants need magnesium to synthesize chlorophyll. Magnesium is so necessary to cellular chemistry that some researchers refer to it a “basic building block of life.”[4]

From where we’re sitting, that means that if you’re magnesium-deficient, you’re partially… not alive.

(Cue The Walking Dead theme. Don’t panic, but most of the people around you are low-magnesium zombies. Just… keep your eye on them. Especially if they start making gurgly, raspy sounds).

So, how did we get so magnesium deficient?

Modern agricultural practices have stripped our soil of minerals like Mg, so we get less in our food.

Modern agricultural practices have stripped our soil of minerals like Mg, so we get less in our food.

Well, like many problems facing our species, we’ve done this to ourselves on multiple fronts:

  • Modern agricultural methods that strip nutrients from the soil. (None more so than magnesium. Check this map to see how your local soil is doing.)
  • Use of pesticides and herbicides that reduce the uptake of minerals by plants.
  • Lack of plant food in our modern diet. Animal foods tend to be magnesium-poor, with certain exceptions. We’ll talk about magnesium-rich foods here in a minute. And junk food, is well… junk.
  • Purification of our water supply. Our ancestors probably got a lot of magnesium from their water. Not us. Routine municipal treatment takes away bad stuff and good stuff, like essential nutrients. Plus, we’ve decided to add fluoride, which is known to completely neutralize magnesium ions. SMRT!
  • Prescription (and OTC) drugs. Antibiotics, allergy and asthma remedies, anti-inflammatories, diuretics, hormone replacements, and oral contraceptives are notorious magnesium-depleters.[5]
  • Our calcium intake (mainly in the form of dairy), which is way too high. Calcium and magnesium are synergistic minerals, meaning they work together when taken in the right ratios, but when one is taken in excess the other can’t function properly.
  • Carbonated beverages.[6] Phosphates in soft drinks bind with magnesium and calcium preventing their absorption by the intestine.
  • Our sugar addiction. Sugar suppresses your body’s ability to absorb and synthesize other nutrients. Avoid sugar as though it were poison. Hint: it is.

OK, I get it. Magnesium is super-important. But what about acne?

Well, here’s where things get really interesting. The research is clear: magnesium does a bang-up job at fighting almost all the major underlying causes of acne.

Let’s look at a few of the big ones…

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Magnesium fights anxiety and stress

You probably already know from experience that your acne gets worse in times of stress. Studies abound[7] [8] [9] showing the link between stress and skin problems.

When we’re stressed our adrenals work hard, releasing adrenaline and cortisol, hormones that help us jump into action if we’re in danger—which is a good thing, so long as the situation is temporary. But when we’re in a state of chronic stress, these hormones don’t switch off. Cortisol builds up, causing the skin to secrete more sebum, clogging your pores, and worsening acne.

Enter magnesium.

Magnesium earns its cred as the “relaxation mineral.” As one doctor put it, magnesium is “the original chill pill.”[10]

Magnesium supports your adrenal function. When cortisol gets released into your system, your kidneys release some magnesium to compensate. Essentially, magnesium regulates and dampens the effect of the stress hormones when they’re no longer needed. It says: “Chill, bro. We got this.”

Magnesium is also needed to synthesize serotonin, which is your “feel good” hormone, the one that makes you want to get up in the morning and do things and enjoy life. Patients suffering from depression, for example, invariably have low serotonin levels.[11]

So, bonus: in addition to being the original chill pill, magnesium is also the original “happy pill.”[12]

Upping our magnesium intake, accordingly, helps us manage stress and anxiety, and by doing so, helps us manage acne.

But magnesium is not enough by itself. Chronic stress can overpower and use up your magnesium stores—basically, it eats magnesium like candy. (Yet another big factor depleting everyone’s magnesium.) When your magnesium stores run low, your blood vessels tighten and blood pressure goes up, which magnifies the effects of the stress, which makes the blood pressure worse… etc.

It’s a bad spiral to be on, and it invariably shows up on the skin.

So, the idea here is not to eat a bunch of magnesium just so we can go on enjoying our stressful lives! Gotta work on reducing the stress, too.

Note: if you’re a heavy caffeine user you might consider, uh… not being one. Caffeine has exactly the same effects on the adrenals as stress, triggering the release of the same damaging hormones.[13] This too, uses up our already under-supplied magnesium!

Magnesium improves your sleep

Magnesium helps you feel relaxed and sleep well at night - which is important for healthy skin!

Magnesium helps you feel relaxed and sleep well at night – which is important for healthy skin!

You knew that a good night’s sleep is essential for clear skin, right?

Just look at some of the effects of insufficient sack time:

  • It has exactly the same effect of you, physiologically, as stress, including the same increase in cortisol.
  • It makes inflammation worse, resulting in worse acne.
  • It worsens insulin resistance.
  • It weakens your immunity, making it difficult to fight off P. acnes bacteria.

How does magnesium help with sleep?

We’ve already talked about how it down-regulates cortisol. Cortisol keeps you awake and “wired,” essentially keeping you ready to fight off enemy combatants or run away from a bear… whether those are legitimate threats or not. Magnesium tells the cortisol to chill. “Like, I think we’re good on the whole ‘bear-situation,’ okay, bro?” (Apparently magnesium is some kind of super-chill hippie/surfer-dude in my head. Probably not too far off.)

Magnesium also helps the muscles relax. In fact, without it, they couldn’t relax. Obvious benefits for snooze time.[14]

We also mentioned magnesium being necessary to synthesize serotonin. Serotonin, in turn, is a precursor for melatonin, your “sleepy-time” hormone. One study[15] had elderly patients taking a 500mg daily dose of supplemental magnesium for eight weeks. Compared to a placebo group, the magnesium-takers all showed a boost in melatonin levels (and a decrease in cortisol).

As a bonus, getting more serotonin also boosts your immune function.[16] Take that, P. acnes bacteria!

And, finally, as we already discussed, magnesium helps with anxiety – so you’re not lying there having mini-panic attacks instead of settling down for a nice, deep slumber.

All good things for getting some quality sack time, and therefore, for reducing acne.

Magnesium helps fight insulin resistance

Insulin is another hormone, like cortisol, that’s a good thing in small doses. It helps keep your blood glucose (sugar) low, which would otherwise be toxic to your system, shuttling it off into your body’s cells to be used as energy instead. But when we produce too much insulin (like when we overload our diets in sugar) the body’s cells stop accepting all the excess glucose—they become resistant. This is the short road to metabolic syndrome and diabetes.

Not a road you want to be on.

Insulin resistance, as it turns out, opens up a world of acne-related problems: sebum production goes up, dying skin cells clog our pores, and inflammation gets worse.

Here again, it’s magnesium to the rescue. Magnesium has been shown to slow and/or reverse the effects of insulin resistance.[17]

One study from 2013[18] showed that non-diabetic individuals who were showing metabolic syndrome symptoms (technically “pre-diabetic”) were able to lower their metabolic markers for insulin resistance 71% just by increasing their dietary magnesium. Wow. Pass the magnesium, please.

Another study[19] found that increased magnesium intake was able to slow the progression of pre-diabetic/insulin resistance into type 2 diabetes. The study participants (nearly 300 of them) had 37% lower risk for diabetes progression than the general population.

Yet another study from Japan confirmed this: magnesium was able to “significantly prevent” the incidence of type 2 diabetes.[20]

Again, we’re not suggesting magnesium as a crutch for your poor diet. Fix the diet and get your insulin under control, for sure.

But based on this research, magnesium is going to help your efforts in a big, big way!

Magnesium helps the gut thrive

Your gut needs magnesium to be healthy, and a you need a healthy gut to be acne-free.

Your gut needs magnesium to be healthy, and a you need a healthy gut to be acne-free.

Well, it’s not a good article unless we end up on the subject of poop at some point. 🙂

We’ve talked before about the link between gut problems, specifically an imbalance of good guys and bad guys in your gut microbiome, and how it relates to acne. Everything acne-related—inflammation, nutrient absorption, skin chemistry, immunity—is worse when your gut is out of whack. [21]

And a magnesium deficiency only makes matters… umm, worse-er.

As one study[22] showed, mice fed a magnesium-deficient diet had significantly lower concentrations of beneficial gut bacteria.

A pretty clear-cut result.

It makes sense. Your body uses magnesium to activate enzymes to help break down your food. If you don’t get enough magnesium, down the road you’re looking at all the problems that poor digestion brings a-knocking: Crohn’s disease, leaky gut, SIBO, etc. In all these situations, the bad (pathogenic) bacteria thrive, and the good guys die out.

Also, magnesium is necessary for the contraction and relaxation involved in bowel movements. Insufficient magnesium causes slower bowel emptying, which also causes problems with your gut flora.

Basically, magnesium makes the parasympathetic nervous system work better, which makes the muscles contract and relax better, moves things along, improves digestion, and allows the gut and microflora to do their work in a timely fashion.

In short: more magnesium = happy pooping = a happy gut = happy skin!

Magnesium is anti-inflammatory

No need to belabor the point here. You’ve likely read or heard all about the damaging effects of chronic inflammation. As we’ve discussed before, when inflammation shows up on the skin as acne lesions, it’s a sure bet you’ve got some serious damage going on internally as well.

So, what does the research on magnesium and inflammation say?

In one study on more than 3000 post-menopausal women,[23] increased magnesium intake was responsible for reducing three separate biomarkers for inflammation: CRP (C-reactive protein), TNF (tumor necrosis factor alpha), and IL6 (interleukin-6).

Magnesium is also a precursor for vitamin C, and specifically helps vitamin C express itself in the skin, where it has antioxidative effects[24] . Antioxidants are effective at preventing something called sebum peroxidation, which is when free radicals damage the skin’s sebum, lowering its oxygen content, and making it an ideal environment for an anaerobic bacteria, P. acnes, to thrive and reproduce.

Oh, plus magnesium helps activate another skin-vital nutrient: Vitamin D.[25]

Magnesium deficiency has also been tied to a reduction of glutathione, another key antioxidant your body uses to fight off damage from free radicals.[26]

Magnesium also prevents inflammation by inhibiting e-selectin,[26] which is a molecule responsible for inflammation in the skin. Basically, when your skin is damaged, e-selectin directs inflammation to the site to help the healing process. When the skin is chronically damaged (owing to ongoing poor lifestyle choices such as smoking, poor diet, stress, etc.) then the e-selectin never shuts off. Red, swollen, painful acne lesions are the result.

Bottom line, getting plenty of magnesium helps your body turn off all the inflammation, both systemically and locally, on the skin.

OK, so magnesium is great for the skin. What are some magnesium-rich foods?

Eat magnesium-rich foods from the "A-List" daily.

Eat magnesium-rich foods from the “A-List” daily.

The A-List:

  • Green, dark, leafy vegetables (the darker the better): Spinach, kale, swiss chard, collard greens, etc.
  • Fish: sardines, mackerel, tuna
  • Seaweed, spirulina, and kelp
  • Avocados
  • Bananas
  • Dried fruit: figs, prunes, apricots, raisins
  • Dark chocolate

Some sources also say (we’ll call this List B):

  • Nuts and seeds
  • Beans and lentils
  • Whole grains
  • Dairy

A word of caution with List B, however. Some things may be superficially high in magnesium but have anti-nutritional properties which completely negate the benefits. Nuts, for example, contain a lot of omega-6 fats, which can worsen acne if they’re not consumed sparingly.

Also, grains, nuts, and seeds contain a lot of phytic acid (another anti-nutrient, like sugar) which actually hinders your absorption of magnesium.[27]

Same goes for the high calcium content of dairy. (You’ll want to avoid dairy anyway if you’ve got acne.) Calcium and magnesium occupy the same pathways as far as the intestine is concerned, so one can “crowd out” the other. If you’re over-consuming calcium, the intestine just won’t let the magnesium into the nutrient party.

Stick to List A, and you’re giving the body what it wants, with little to no downsides.

(Hmm, maybe those zombies on Walking Dead should be going for leafy greens instead of gnawing on human flesh. Probably not as dramatic a show, though. “Oh NO, they’re swarming the garden. Not the collard greens!!.. NOooo!!”)

Alright, so that covers your food sources.

Now it’s time for some grim math.

Consume all the magnesium-“rich” food you want, you’ll still be in magnesium poorhouse. The standard daily intake recommendation is around 300-400mg of magnesium, and some recommend even higher amounts like 800mg to 1000mg.[28]

One cup of raw spinach has a whopping 24mg of magnesium. Are you going to eat 33 cups of spinach every day? I doubt it. A can of sardines has about 36mg of magnesium. Again, do the math: 22 cans of sardines today? Yeah, didn’t think so.

Plus, the magnesium measurements in our food were all taken by the USDA years ago. All those factors contributing to magnesium depletion haven’t gone away, so there’s likely even less magnesium in our food today.

Food, these days, unfortunately, just isn’t up to the task.

(With the possible exception of kelp. More on this in a minute)

So should I take magnesium supplements?

Since it's nearly impossible to get enough Mg from food alone, take a daily supplement, too.

Since it’s nearly impossible to get enough magnesium from food alone, take a daily supplement, too.

In a word, yes.

The case for supplementing magnesium is strong—more so than for any other mineral supplement out there. As we’ve seen:

A. It’s absolutely vital for a healthy, functioning, energetic body (and, therefore, for clear skin) and…
B. There’s just not enough of it in our food, even if we’re being diligent about consuming magnesium-rich foods.

Listen, there are many cases where we’ve recommended ditching the supplements in favor of eating real deal, a.k.a. plants and animals.

This isn’t one of them.

Eat the real food, of course.

But seriously consider adding some supplemental magnesium because, unfortunately, your food just isn’t cutting it.

A little anecdotal “evidence” for supplementing

As an experiment, I tried tracking my food intake of magnesium for two weeks. I didn’t modify my intake of magnesium-rich food—I just wanted to see where I was at.

I eat ocean liners of sardines. I also eat an unholy crap-ton of green, leafy vegetables—just… mountains of it. (Even the real dark, bitter stuff that no one likes, like kale, and swiss chard, and dandelion greens… blech.)

Now, I knew from my research that I probably was a wee-bit deficient in magnesium, but I predicted I would at least be in the upper percentiles.

Boy, was I wrong.

After averaging out two weeks, I was shocked to find my magnesium was holding fast right at about 55% of the RDA.

Fifty-five percent??

Shocking. Knowing what I now know about the importance of magnesium, this called for a change.

Without changing my diet, but adding magnesium supplements (about 500mg a day), here’s a few things I noticed:

  • WAY more consistent energy. No afternoon slumps, just a steady feeling of alertness all day long.
  • Less coffee craving.
  • Less salt craving. Could my body actually be begging for magnesium when I’m giving it sodium? Hmm…
  • Less worry/anxiety, and improved mood in general (that serotonin is magic stuff).
  • Better concentration. Instead of being distracted every few minutes, I found myself able to focus on a task for longer, every now and then looking up at the clock in surprise to find that an hour had passed without me noticing!
  • Better and more consistent bowel movements. (Boy, we really get up front and honest in these things, don’t we?)
  • Better and more solid sleep. I’ve always thought of myself as a light sleeper, waking up several times a night, and sometimes even sleeping in little shifts, like 3-4 hours, then up for a couple of hours, then back to sleep for a couple of hours, etc. Since the magnesium: one solid shift of sleep, every night. And waking up refreshed, without a need for a siesta later on in the day. Que bueno!
  • Improved skin. Yep, this is the one we’re really after. I sometimes get a little rosacea under my eyes. It invariably comes back when my gut is out of balance, and in the past I’ve been able to control it using probiotics. This time, however, magnesium (with no probiotics) cleared it up nicely!

Now, all of these effects were predicted by the research, which I was aware of before taking the supplements. Could there have been some placebo effect? Sure.


But I really wasn’t expecting the variety of issues that magnesium seemed to address for me. I thought I might experience one or two little improvements, like lower anxiety and improved sleep. But to also experience an increase in energy, reduction in salt craving, better bowel movements, better sleep, and better (less-inflamed) skin? Hmm.

Suddenly, multiple health issues (which, in my mind, had been unrelated) all seemed to be improving at the same time. It certainly seemed to form a picture.

Have I been underfeeding myself magnesium all these years?

Turns out, most of us are.

If you aren’t currently taking a magnesium supplement, I’d highly encourage you to try one, even if it’s just for a few weeks. If you experience even one of the effects that I did, especially the skin clearing, there’s a pretty good chance your body has been crying out for some magnesium for some time now.

Which of the bajillionty-billion magnesium supplements out there should I take??

Go ahead and Google magnesium supplements. We’ll wait.

Name soup, right? No doubt you ran into a list along the lines of:

  • magnesium oxide
  • magnesium hydroxide (aka. milk of magnesia)
  • magnesium citrate
  • magnesium orotate
  • magnesium chloride
  • magnesium lactate
  • magnesium carbonate
  • magnesium glycinate
  • magnesium malate…

…etc, etc.

Phew. Well, one’s as good as another, right?


They all have their uses, but they differ in bioavailability, quality, and the issue that they’re targeting. Magnesium “–ides,” for example tend to be used as nothing but stool softeners. That’s swell, but it’s not really our end game here. We’re looking to fix our magnesium deficiency and thereby address all the issues that give rise to acne (stress, gut issues, inflammation, etc.).

I’ve taken magnesium lactate before, on the recommendation of a holistic doctor, specifically to address digestion issues I was having at the time, and it did help fix the gut and make my skin better. This was the brand I used, if you’re interested.

Note: This and the following supplement links are affiliate links, which means we receive compensation if you make purchases using these links. Visit our disclaimer page for more information.

Magnesium glycinate, while it doesn’t have the highest total magnesium content, is nevertheless touted as one of the most bioavailable forms out there. This is the version of magnesium that’s believed to be the best at making up for an overall deficiency. This is the one I’m taking now, with all the benefits already noted. There are a few different ones on the market, but the nice thing about Pure Encapsulations is that they focus on giving you the purest form of the mineral or vitamin possible, with no weird additives or fillers. The ingredients list speaks for itself: magnesium glycinate, ascorbyl palmitate (a fat-soluble form of Vitamin C), cellulose (what plant cell walls are made of), and water. That’s it.

Let us know if there’s another one you’ve tried, and how it worked for your skin!

How much magnesium should I take?

You know at the end of a commercial when they say “results may vary”? Same goes here.

There is no universal prescription for magnesium. What’s good for you may not be good for your spouse, or for your neighbor, or your pet budgie. Like most things, it depends on a bunch of factors, like bodyweight, metabolism, how much calcium and potassium you’re getting, how depleted you already are on magnesium, how bioavailable your magnesium source is, and if anything else you’re eating is enhancing the bioavailability. (We’ll talk about a few bioenhancers here, shortly.)[29] You may get excellent results with 250mg a day, or you may be one of those that need 700mg.

Experiment with what works for you. It’s generally a good practice to start off with a low dose, then gradually increase it.

Thankfully, unlike a lot of other supplements out there, it is really, really hard to achieve toxicity levels with magnesium. The only people that really need to worry about OD’ing on magnesium are those with kidney problems. (If you’re not sure whether you have impaired kidney function, or if you’re taking diuretics of any kind, consult a doctor before trying anything new with magnesium… but you knew that, right?) This is a good resource if you’re worried about any contraindications or drug interactions.

Assuming a good, healthy set of kidneys, your body has a nice, obvious tell when you’ve gone a little overboard with magnesium: your poop gets loose.

So start off with a minimal dose per day, say one 100mg capsule. (Remember, you should hopefully be getting a few hundred mg’s from your food.) Then try 200 mg. Then 300, etc. When things start getting a little too umm… motile… for your liking, then drop the dose back down by one.

Yay! Your body is finally getting the levels of magnesium it has been begging you for!

Is there anything I can do to increase the bioavailability of magnesium?

Some people talk about taking a calcium supplement along with magnesium to increase it’s bioavailability. We think this is based on a misunderstanding. The two minerals operate synergistically, yes; one can’t function without the other. But, as we discussed, most people are getting too much calcium relative to magnesium already. Upping the calcium only increases the need for magnesium! (And too much calcium relative to magnesium can lead to muscle spasms, stroke, or heart attack![30] Gulp.)

Dr. Mercola suggests a 1:1 ratio of calcium to magnesium as optimal.[31] . If you’re really concerned about it, try tracking your nutrient intake for a couple weeks and see where you’re at. Don’t worry about the total amounts; just pay attention to the ratio between the two minerals. If you’re like most folks, we’re betting it’s the magnesium you need to work on.

Maybe the best thing you can do for bioavailability is avoid all the things that hinder or harm magnesium absorption (duh!):

  • Pesticide/herbicide-laden produce. (Buy from an organic farm or CSA. Even better, start growing your own garden!)
  • Fluoridated water
  • Prescription drugs
  • Dairy
  • Soda drinks
  • Excess caffeine
  • Sugar
  • High phytate foods like whole grains, seeds, and nuts
  • Stress

Are there any other ways to get more magnesium?

Yep, glad you asked!

Absorb magnesium through your skin by taking Epsom salt baths.

Absorb magnesium through your skin when you take Epsom salt baths.

  • Take Epsom salt baths. This is great way to absorb just the right amount of magnesium through the skin. Now you know why Epsom salt baths are so relaxing: the magnesium!
  • Drink mineral water.
  • Apply magnesium oil (affiliate link) to your skin. Not on the face—no need to mess with the skin chemistry there. Just apply it in a highly absorbable place, like the rib cage or inner arms so it starts to go to work in your cells. Let your body direct the magnesium to where it needs it the most! Some people report an initial burning sensation with magnesium oils. If this happens to you, wash it off, and dilute the oil 50/50 with water. Also, never put magnesium oil on a place you shave (armpits, ladies!) – it will burn!

Oh yeah… we mentioned kelp. This Huffington Post article claims kelp has 750mg per serving. For a food source, that’s just… incredible! Of course, we’re not exactly sure where they got that measurement, or how accurate it is. On the back of the Maine Coast Sea Vegetables Kelp (affiliate link) they recommend, for example, it says serving size 1/3 cup (7g): magnesium = 4% of RDA.)

Anyway, it’s worth looking into. Seaweed, in general is a known powerhouse of multivitamins—it’s the only plant food on the planet that provides every mineral required by the human body. If you’ve tried kelp before, or you have another source of magnesium you’ve tried, let us know how it worked out for you in the comments!

And, as always, remember that we’re not suggesting you to try just one thing in isolation to cure your acne. Adding magnesium to your life should be just one small part of a holistic approach that addresses diet, lifestyle, stress—the whole works. If you want the complete breakdown of everything we recommend for acne so you can start getting clear today, please check out the book Clear Skin Forever!

(Though, to my knowledge, the book has nothing to say about zombie-defense. You’re on your own for that one. Maybe in a future edition?)

Key Takeaways

  • Magnesium isn’t just nice, it’s necessary. And, if you’re like most humans, you’re not getting remotely enough of it.
  • Magnesium addresses several huge acne causes, namely: it fights stress/anxiety, gives you better sleep, it helps regulate your insulin and blood sugar levels, it helps the gut flora thrive, and it’s anti-inflammatory. As far as acne goes, that pretty much runs the table!
  • Some great food sources for magnesium are dark leafy greens, fish, seaweed, bananas, and dark chocolate, BUT…
  • Food sources are not enough! Definitely consider taking a magnesium supplement, and experiment with the right doses for you.
  • You might also experiment with Epsom salt baths, magnesium oils, and finding a good source of mineral water. And, eww… kelp.
  • Remember you’re not alone in your struggles with acne! When you check out the Clear Skin Forever e-book, you’ll also get access to the members-only CSF Forum, where we discuss everything acne-related (and sometimes beyond 😉 ).
Sources (click to expand)

  1. Available at: Accessed July 1, 2016. ^
  2. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated?. Nutr Rev. 2012;70(3):153-64. (link) ^
  3. Available at: Accessed July 1, 2016. ^
  4. Available at: Accessed July 1, 2016. ^
  5. Available at: Accessed July 1, 2016. ^
  6. Vartanian L, Schwartz, M, Brownell, K. Effects of Soft Drink Consumption on Nutrition and Health: A Systematic Review and Meta-Analysis. American Journal of Public Health. 2007;97(4):667-675 ^
  7. Available at: Accessed July 1, 2016. ^
  8. Chiu A, Chon SY, Kimball AB. The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress. Arch Dermatol. 2003;139(7):897-900. ^
  9. Reorganized text. JAMA Otolaryngol Head Neck Surg. 2015;141(5):428. ^
  10. Available at: Accessed July 1, 2016. ^
  11. Available at: Accessed July 1, 2016. ^
  12. Available at: Accessed July 1, 2016. ^
  13. Ping J, Lei YY, Liu L, Wang TT, Feng YH, Wang H. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells. Chem Biol Interact. 2012;195(1):68-75. (link) ^
  14. Available at: Accessed July 1, 2016. ^
  15. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-9. (link) ^
  16. Mössner R, Lesch KP. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun. 1998;12(4):249-71. (link) ^
  17. Geiger H, Wanner C. Magnesium in disease. Clin Kidney J. 2012;5(Suppl 1):i25-i38. ^
  18. Wang J, Persuitte G, Olendzki BC, et al. Dietary magnesium intake improves insulin resistance among non-diabetic individuals with metabolic syndrome participating in a dietary trial. Nutrients. 2013;5(10):3910-9. ^
  19. Available at: Accessed July 1, 2016. ^
  20. Hata A, Doi Y, Ninomiya T, et al. Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study. Diabet Med. 2013;30(12):1487-94. ^
  21. Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis – back to the future?. Gut Pathog. 2011;3(1):1. (link) ^
  22. Pachikian BD, Neyrinck AM, Deldicque L, et al. Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. J Nutr. 2010;140(3):509-14. (link) ^
  23. Chacko SA, Song Y, Nathan L, et al. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care. 2010;33(2):304-10. (link) ^
  24. Lee WJ, Kim SL, Choe YS, Jang YH, Lee SJ, Kim do W. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes. Ann Dermatol. 2015;27(4):376-82. ^
  25. Carpenter TO. Disturbances of vitamin D metabolism and action during clinical and experimental magnesium deficiency. Magnes Res. 1988;1(3-4):131-9. (link) ^
  26. Available at: Accessed July 1, 2016. ^
  27. Coudray C, Demigné C, Rayssiguier Y. Effects of dietary fibers on magnesium absorption in animals and humans. J Nutr. 2003;133(1):1-4. ^
  28. Available at: Accessed July 1, 2016. ^
  29. Available at: Accessed July 1, 2016. ^
  30. Available at: Accessed July 1, 2016. ^
  31. Available at: Accessed July 1, 2016. ^


  1. Idara says

    Awesome post! I love adding coconut oil to my steamed vegetables and my smoothies. I tried it on my face and found out the hard way that it breaks me out. But I haven’t had that issue with hemp and grapeseed oil.

  2. Idara Hampton says

    Thank you for explaining epigenetics so clearly. It’s very easy to follow. Congrats on clearing your skin. Your story is inspiring.

  3. Idara says

    This is such a well researched and well written article. B5 is great for the skin. I also love B6 and B12 for boosting energy, promoting a healthy luteal phase, and stopping PMS.

  4. Idara says

    Great post! Understanding hormonal imbalances isn’t always easy, so thank you for writing an informative and easy to follow article with helpful tips.

  5. wendy says

    There is no official link between iron and acne in science research but antidotally I believe there is. My daughter used prescription acne creams for a couple of years with only modest improvements to her skin. She recently was prescribed an iron supplement, her iron levels were on the low side of normal, because of her low energy state and, voila, Not only does she feel more energetic, her face is very noticeably improved and much smoother in, just days. She is a big meat eater. Who knew iron can be hard to absorb?

  6. Srey says

    I love this post! I recommend this book “inheritance” by Sharon D Moalem. It talks a lot about genetics, and could be helpful to understand more about epi genetics, and our human genome.

  7. Mike says

    Why do you say that coffee negatively affects muscle since there is like a bunch of evidence that shows the caffeine from the coffee actually helps build muscle and burn fat. Of course this is when you take black coffee without any sweeteners. I have read so many articles that talk about consuming coffee in a fasted state leading to positive muscle gains you can find them easily too

    • Devin Mooers says

      Hey Mike! Interesting point here. I found this study:

      …Which says that you habituate to the caffeine in a few days’ time, meaning your morning coffee no longer stimulates over-production of cortisol once you adapt to drinking coffee daily. However, the study still found that a 1:00 PM cup of coffee boosted cortisol levels higher than normal (though the study only ran for 5 days of caffeine habituation). My personal experience is that coffee just makes me more stressed out in response to stressful events, which includes cortisol release. But I haven’t read the articles you have about fasted-state coffee drinking leading to muscle gains – I wonder if this is just due to metabolic rate increase from the caffeine? In any case, if coffee floats your boat and treats you well, go for it!

    • Devin Mooers says

      Hey Julie! I’m not totally sure on this. That still sounds like a good range. I was going based on a Dr. Mercola article, which I can no longer find (the link is broken). I am far from an expert on what ideal ferritin levels should be!

    • Rhonda says

      I will interject with a personal anecdote about Ferritin levels. I have a genetic disorder called Hemachromatosis. It causes iron from the food I eat to get into my organs and my body can only release it through phlebotomy (donating blood). My Dr noticed a high ferritin level and high liver enzymes on a blood panel and on a hunch she ordered a DNA test for this. If you are suspicious that your ferritin levels are out of whack, ask for this test. This condition is very common especially if you are of Irish or Scottish descent. It’s a lifelong condition but the remedy is easy because you just have to have your levels checked regularly and donate a pint of blood to balance your levels. I am so grateful my doc was smart enough to call for this test. Having this disorder and not taking care of it can lead to liver damage and heart attack. It’s hereditary and if you do have it, all of your nearest relatives should test for it too. Hoping it’s not the case for you, and wishing you all the best!

      • Devin Mooers says

        Kudos to your doc for finding this!! I’m so glad you know now. I had a genetic test done a few years ago, and ruled out hemachromatosis (at least current knowledge of it). So I guess it was just from my diet. And I do have a fair amount of Irish + Scottish in me. Go figure! Great thing to check for, though, as you just found out!

  8. Katy says

    I’m 25 and I have very irregular periods (which have never been regular) and acne since puberty. I got literally all my hormones checked and everything came out normal. Does anyone have an explanation for this?

    • Devin Mooers says

      Hey Katy! I don’t put much stock in hormonal tests, blood tests, saliva tests, or related “snapshot” health tests. I don’t think they’re a very accurate reflection of long-term reality, and don’t often give very useful information for clearing acne (in my experience). The fact that you have irregular periods right away shows that something’s up with your hormone levels, and/or some basic nutrient levels like vitamin A, utilizable iron (don’t go taking iron pills though!), and/or maybe some toxin overload issues. There are lots of things that feed into having a normal cycle, and a hormone test isn’t going to tell you what needs to be fixed.

      Are you drinking fluoridated water, do you know?

      Also, do you want to give an overview of what your current diet is – the more detail the better! – and any pills/supplements you’re taking? I can see if anything jumps out!

  9. Johnny Cox says

    Hi. Im going to say that Im afraid to eat coconut because of acne. Chocolate of any kind gives me acne too. Even fish oil. All these oils do it to me. I used to suspect leaky gut causing me breakouts. All these oils ruin my skin. Whey concentrate and isolate too! Someone said “keep eating the Extra Virgin Coconut oil, It’s just die-off!! It will stop soon” But it does not stop. I get brutal acne from it. Tempted to try again after reading this, but it scares me. My acne is so painful..

    • Devin Mooers says

      Hey Johnny! Really sorry to hear about your experience with so many oils/fats giving you acne. Huge bummer! Frustrating not to know whether it’s from die-off or detox, or just an adverse reaction. (I will say that whey isolate/concentrate both give me acne as well!)

      Couple questions… are you using organic coconut oil, or non-organic?

      Also, do you want to post a mini diet overview right here? I can see if any major red flags come up.

      Finally, are you drinking fluoridated tap water? (And/or using fluoride toothpaste?) Wondering if these fats/oils might be causing a detoxification of fluoride, causing transient acne.

    • Devin Mooers says

      Hey Ashley! I think it’s okay in really small amounts as a garnish or flavoring, but it’s very high in PUFA so I wouldn’t make it a main cooking or salad oil. Toasted sesame seed oil is even a bit more risky because of the toasting process damaging more of the PUFA (and the protective vitamin E found in raw sesame oil).

      What are you wanting to use sesame oil for? Maybe I can suggest a skin-friendly alternative!

  10. Kris says

    Hi Devin,
    Great research, thank you for linking the sources. I’ve suffered with back acne for years. I eat a mostly plant based diet, so I’d call myself a flexitarian (95% plants, 5% grass fed-organic animal). Before that I did mostly Paleo, therefore lots of fresh plants, but still a lot of organic meat/poultry.
    From recent testing, I have low iron stores (ferritin), normal iron (since I suppliment), and low iodine (I now supplement—-boyfriend has shellfish allergy…). I take vitamine A and Magnesium as well.
    I’m game to try anything thats humane and organic even if its not a plant based suppliment, but I would be interested in the Frankin-rice you mentioned since I try to avoid dairy due to an intolerance (causes me inflammation and IgG testing shows markers). If the colostrum is derived from cows or colostrum is from humans, wouldn’t in theory the human one be closer to what we need? Albeit odd to consider!!
    I’ve also looked for a non-bovine ferritin supplement, but it seems I may need to take the bovine one as the plant ones are just more iron (leading to excess). I just want to be humane in my choices, with no added hormones from the cows, etc. With all that said—I’m open to anything—as my skin and other health issues are the number one priority! Any product tips would be greatly appreciated. I use Pure Encapsulations too. 😊 Thank you!

    • Devin Mooers says

      Hey Kris! Sorry for the epic delay on this, I haven’t checked blog comments in a long time. My fault!

      How low is your ferritin? Did you get liver enzymes checked? It’s quite possible to have low ferritin, but also have an overload of unusable iron stored up in your liver. Taking additional iron supplements on top of that, if that’s the case, isn’t a very good idea. Liver enzymes (and/or GGT) can help point to iron overload in the liver. (See my iron article for more info on tests.)

      What kind of iron are you supplementing with?

      Doubt you’ll find human-sourced colostrum, though it’s an interesting idea! 🙂

      Are you interested in lactoferrin for reducing your iron levels, or for boosting your ferritin? There are definitely other, more effective ways of modulating ferritin, I think (see the iron article linked above for way more info on all the iron stuff, including why I think many people may have an iron overload problem even if ferritin levels don’t show it). I’d target the iron-utilization-boosting nutrients listed in the iron article, personally.

      Also, how much iodine are you taking? What form?

      Finally, have you thought about A2 milk as a skin-safe dairy option, that would give you some lactoferrin in a whole food form?

  11. Donna says

    I actually test low for iron. My Tibc, Total Iron, Iron Saturation, and Ferritin are all low.
    It was recommended for me to take Lactoferrin with an iron supplement to properly increase my iron.
    I’m confused about your article because it makes me second guess my situation. You don’t believe ANYONE is actually low in iron?

    • Devin Mooers says

      Hey Donna! How low are we talking on these numbers?

      I definitely think there are a small number of people who are actually low in iron, but I think it’s probably a lot fewer people than most doctors think. Often, if you have iron dysregulation, excess iron gets stored up in your liver, which doesn’t show up one these blood tests. If you’re lacking in one of the co-factors necessary to use iron properly (vitamin A, molybdenum, vitamin C, copper, ceruloplasmin, vitamin B12, etc.), you can get excess iron deposits in the liver combined with low circulating iron. When you add a plain iron supplement on top of that, without addressing the deficient co-factors, you can worsen the problem. Did you happen to get your liver enzymes and/or GGT tested? That can sometimes indicate excess iron storage in the liver. But keep in mind I have zero clinical experience in all this and just going based on the all the research I’ve read (and my own iron overload problem).

  12. jay,s says

    hi, suffering from acne for 20 years and a rediculolus amount of money spent on “solutions”i tried a newer supplement that’s called acne block that contains lactoferrin,found it on amazon.. it actually was/is one of the only supplements I have tried that actually helped..

    • Devin Mooers says

      Great to hear you got good results from lactoferrin! The science is sound behind why it works, helping to reduce iron overload. Good stuff.

  13. Sara says

    Would eating liver or taking a dessicated liver supplement cause iron overload? I would like to get more vitamin A, but am concerned about the extra iron I would be getting.

    • Devin Mooers says

      Hey Sara! Wise to be cautious about this. Do you have reason to suspect you have existing iron overload? Curious about that, I’ve suspected that in myself for a while now, and have been avoiding liver for that reason. I’m taking Pure Encapsulations vitamin A instead.

    • Sarah says

      Suggesting vegans/Vegetarians have a greater risk of iron deficiency is incorrect. There are at least as many meat-eaters as vege people deficient in Iron. Meat is not an efficient source of iron for human beings. Cutting out animal products goes along way in clearing up acne.

      • Devin Mooers says

        Hey Sarah! I actually agree with your first point now, but differ in the second. I think many people, vegeterians and meat-eaters, have an iron overload problem. This is pretty new to me, but the research seems sound. Turns out you can have anemia AND iron overload, due to iron getting deposited in your liver, but a lack of nutrients that are required to put iron into hemoglobin, like vitamin C, vitamin A, molybdenum, and copper. I also think the research strongly points to heme iron from meat being an excellent source of iron – much more absorbable than plant iron – but I now think eating too much meat leads to iron overload, because your body can’t shut off absorption from heme iron like it can from plant iron. If you’re curious to learn more, I just posted a huge article on iron and acne two days ago:

        Iron and Acne

        I think this is really an unusual perspective, and the opposite of what most people will tell you! Curious to hear your thoughts! 🙂 (I’m actually eating mostly vegetarian these days, due to trying to reverse my iron overload problem, and, yes, the environmental impact.)

  14. Taylor says

    So if I maintain a Paleo/Whole 30 diet that includes high quality meats and seafoods and I do not eat any of the iron-fortified foods or foods that inhibit lactoferrin – my body should be creating lactoferrin on it’s own in a healthy manner and I likely do not need to supplement it, correct?

    • Devin Mooers says

      Yep, exactly! Historical iron overload can be an issue, less so for menstruating women due to the continual iron dumping outlet. Bloodletting was effective back in the day for many diseases due to iron removal! Men don’t have such a built-in iron removal system (perhaps explaining why men tend to live shorter lives than women – iron buildup!). I’m not 100% sure how effective lactoferrin supplementation is for addressing built-up iron overload. Morley Robbins ( is the guy to read about on all the iron issues.

  15. Christina says

    I’m confused. I was just about to purchase some FCLO for my teen daughter to help her with her acne and now I stumbled across your reply where you state you no longer recommend FCLO! Why the change?

    • Devin Mooers says

      Hey Christina! Sorry about the confusion here – I wish we could keep the same recommendations forever, but our knowledge (and the science, and reader experience, etc.) forces us to change our recommendations now and then, and it’s hard to change everywhere all at once! We changed this recommendation because FCLO is basically pure PUFA (polyunsaturated fat), which is more susceptible to lipid peroxidation than other fats, and this is a major contributor to acne, we now believe (lipid peroxidation). The vitamin A in FCLO tends to be very beneficial, but you can get that vitamin A from eating liver, taking desiccated liver capsules, or taking a vitamin A supplement such as this one by Pure Encapsulations. We now think it’s best to reduce the total body load of PUFA as much as possible, rather than trying to boost omega-3s, for instance. Does this make sense?

    • Devin Mooers says

      Hey Sam! That’s actually a really good idea. We currently do not recommend taking FCLO or cod liver oil – we’ve updated our book but haven’t found the time yet to update our cod liver oil blog post – we’ll do that soon! We recommend taking desiccated liver capsules or eating grass-fed liver regularly, or taking a vitamin A supplement like this one:

      Pure Encapsulations Vitamin A 10,000 IU

      Taking vitamin E is a great PUFA defense strategy when you’re eating out at restaurants or for some reason consume a large amount of PUFA. We’re working on a “PUFA Shield” supplement that incorporates full-spectrum E along with some other lipid peroxidation blockers to make it easier for travelers, folks who eat out a lot, etc. to avoid the worst PUFA effects on acne.

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