Fish Oil vs. Cod Liver Oil for Acne: A New Perspective

Fish Oil vs. Cod Liver Oil for Acne: A New Perspective

Sonia taking fermented cod liver oil for clear skin

Sonia demonstrates the joys of taking fermented cod liver oil for clear skin!

What do fish oil and cod liver oil have to do with acne, anyway?

In a nutshell, fish oil – or rather, omega-3 fatty acids – appears to help some people clear up their skin faster.  This is because omega-3s reduce inflammation in a few different ways.

Sounds good, right? Inflammation is a major contributor to acne, so it’s tempting to think it’s a good idea to start taking fish oil. But before you go running to the store or your favorite retail website for a bottle, let me say this: although we used to recommend supplementing with fish oil, we advise against it now.

In fact, taking fish oil may ultimately make your acne worse.

First, I’ll tell you how fish oil “works.” Fish oil contains a large amount of omega-3 fatty acids, particularly EPA and DHA, which interact with omega-6 fatty acids to reduce or end your body’s inflammatory response. When you have a really skewed omega-3:6 ratio in your diet – as in, way too much omega-6 and not enough omega-3 – your inflammation levels skyrocket.

Not good!

And for some years now, people have been using large doses of fish oil to treat inflammation by balancing out those pesky omega-6s.

How does inflammation relate to acne? Well, It’s responsible for the redness and swelling that makes acne so embarrassing. Reduce inflammation, and your acne won’t swell up so much (or get so cherry-red).

Cod liver oil, on the other hand, works to heal acne mainly because it gives you a big boost of vitamins A and D, both of which are critical, acne-curing vitamins. While it also contains some omega-3s, the dosage is far smaller than what you’d get in a dose of fish oil. We do recommend taking fermented cod liver oil, which I’ll explain more later on.

Okay… so what are fish oil and cod liver oil, exactly?

Fish oil is basically oil that’s extracted from fish bodies, while cod liver oil is taken from the livers of codfish. Pretty simple.

And like I said above, fish oil is a powerful source of omega-3s, and omega-3s have anti-inflammatory effects.

What’s the big deal with inflammation?

You see, these days, most of the common Western diet is highly inflammatory.

What does that mean, exactly?

Well, it means that most people are eating way too many foods loaded with omega-6 fats, sugar, trans fats, and gluten, all of which are pro-inflammatory. These inflammatory foods drive your immune system to do insane things, like causing swelling where you least want it – arthritis, for example, and of course, acne. When your immune system is on constant red alert, and it stumbles across a clogged pore on that lovely face of yours, it dives in for the attack! The clogged pore becomes inflamed, red, and swollen, leading to nasty-looking zit-monsters.

You see, if your immune system were healthy and normal, a clogged pore wouldn’t cause a big fuss. Your body would heal the ruptured pore pretty quickly and then go on functioning normally. No big deal! But when your body is in a constant state of hyper-immune-activation and inflammation, any little thing sets off your immune system – and that leads to disastrous consequences for your face.[1]

How do omega-3s affect inflammation?

Before I get to that, let me explain a few things about the essential fatty acids: omega-3s and omega-6s. While there are many different fatty acids in the omega-3 and omega-6 families, only a couple are actually really useful and needed in the body. These are docosahexaenoic acid (DHA), an omega-3, and arachidonic acid (AA), an omega-6.

Arachidonic acid is critical to the initiation of an inflammatory response, which is why it gets a bad rap. However, AA also turns on the cellular machinery that activates DHA, which helps to bring that inflammatory response to an end.

Together, these two fatty acids are a part of an intricate chemical dance in the body that starts an inflammatory response when it’s needed and then stops it when it isn’t needed anymore.

(Another omega-3 found in fish and fish oils, eicosapentaenoic acid, or EPA,  reduces inflammation mostly by interfering with AA… and therefore with the whole process of inflammation and its resolution. It can actually depress growth and immune function, which is why we’re not too excited about EPA.)[2]

As you can see, omega-3 fats – namely DHA – have an incredibly powerful role in quickly resolving inflammation when it is no longer needed.

The key here is your ratio of these omega-3s to pro-inflammatory omega-6 fats. The rub is that if the inflammation-initiating omega-6 fats aren’t balanced by sufficient omega-3s, your immune system goes vigilante on you (boom! Faceful of acne).

Now, if you were eating like a hunter-gatherer of yesteryear – e.g. wild game, tubers, nuts, vegetables, the odd beehive – you’d have an omega-3 to omega-6 ratio of around 1:1 (ideal, by some estimates). But in this day and age, omega-6 fats are in everything – canola oil, safflower oil, vegetable oil, corn, soy, wheat – basically most of the JFBBs (Junk Food Building Blocks) in today’s fast-food world. Most cookies, crackers, snacks, breakfast cereals, and granola bars are made primarily with these JFBBs, which, again, are highly inflammatory. That’s bad news for acne!

In short, you’ve got to optimize your omega-3 to -6 ratio if you want clear skin.

This will help quiet your immune system down, taking it from red alert down to orange alert, yellow, maybe even just “Ready for action, we’re here when you need us!” And that’s where you want it. You want a perfectly functioning immune system that shoots into action when there’s a real problem in your body, not when you get a stinkin’ little clogged pore. And you want an immune system that quiets the heck down when the problem is solved, rather than sticking around for days, partying in your pores and creating red, swollen, painful acne. You’ve had enough of that, right?

So why shouldn’t I take fish oil?

The common wisdom goes like this: fish oil gives you a huge blast of omega-3s (EPA and DHA), which is good because it balances out your omega-6 intake, reducing inflammation.

That seems like a good idea on the surface.

However, I haven’t gotten to the nasty part yet: all omega-3 and omega-6 fatty acids are highly reactive in the body.

Why? Well, they’re polyunsaturated fats (PUFAs). In chem-speak, they contain two or more double bonds, which makes them billions of times more reactive than, say, saturated fat (grass-fed animal fat, coconut oil, red palm oil, etc.). And millions of times more reactive than monounsaturated fat (olive oil, avocados, etc).

Why is this potentially dangerous?

Health researcher Chris Masterjohn came up with a really apt metaphor for PUFAs – he compares them “delicate glass.”

Now, glass is incredibly useful in our modern world (can you imagine windows made from steel?). But glass is also extremely delicate – it shatters easily, fragmenting into a million pieces that spread far and wide across the floor, can cause all kinds of bodily harm, and can take a long time to clean up.

PUFAs are very similar. Like glass, they’re very useful for the body for some critical bodily functions, but they’re extremely delicate. When they “shatter” – i.e., when they get oxidized by a free radical – they set off chain reactions that oxidize other PUFAs, which oxidize still more PUFAs, which oxidize yet more PUFAs – it’s a gigantic, damaging ripple effect.

Worst part? These oxidized PUFAs (known as lipid peroxides) eventually break down into dangerous compounds like malondialdehyde (MDA), which can directly damage DNA and proteins throughout the body.

Oxidative stress like this can damage just about every biological tissue in the body, and – yep, you guessed it – can worsen acne as well.

Wolfing down a bunch of fish oil might reduce inflammation / redness / swelling in the short term, but can create a potentially worse long-term problem of oxidative stress.

(And if you need any additional convincing, consider this: in the longest and one of the largest fish oil trials ever conducted, the heart disease patients taking fish oil had a 30% increase in heart-related death!)[3]

Okay, so what should I do instead?

Better solution?

  1. Focus on getting your omega-6 intake as low as possible.
  2. Slightly increase your omega-3 intake using fermented cod liver oil.

Let’s go over these separately.

How to reduce your omega-6 intake

The main sources of omega-6 are:

  • Sunflower oil
  • Safflower oil
  • Peanut/groundnut oil
  • Cottonseed oil
  • Soybean oil
  • Corn oil
  • Grapeseed oil
  • Canola oil
  • Deep fried foods (which contain large amounts of the above oils)
  • Processed foods (which contain large amounts of the above oils)
  • Walnut oil
  • Flax oil

Here’s a more in-depth list of the omega-6 content of foods from 180 Degree Health: Omega-6 content in common foods.

And if you’re not convinced already, here’s a roundup of the key clear-skin benefits to improving your omega-3 to omega-6 ratio (by reducing omega-6 consumption):

Improving this fatty acid ratio can help…

  • Reduce redness and puffiness of acne lesions.
  • Moisturize your skin naturally, making your skin softer.
  • Reduce stress, preventing excess acne-causing sebum production.
  • Slow down skin cell over-production, keeping your pores open and free.
  • Balance hormone production, making your skin less oily.

In addition to helping clear your skin, a healthier omega-3 to -6 ratio can also provide the following benefits:

  • Reduced joint pain.
  • Improved mood. [4]  [5]
  • Improved brain performance. [6]
  • Stronger hair.
  • More energy.
  • Improved cholesterol levels.
  • Enhanced male fertility. [7]
  • Fat loss. [8]  [9]

That’s a key theme in this blog – by targeting the root causes of acne, you’ll also become healthier, fitter, and more radiant. You’ll be giving your body clean, high-octane food that’s loaded with essential nutrients that perform millions of complex, tiny functions in the body and lead to an awesome, healthy, clear you.

Why you should take fermented cod liver oil (FCLO)

There’s an exception to the “no fish oil” guideline – fermented cod liver oil. Why? Because as I indicated above, it’s an incredible source of fat-soluble vitamins like A and D. Pre-formed vitamin A especially is pretty difficult to get unless you’re regularly eating organ meats (e.g. liver), shellfish, large quantities of egg yolks, and butter. (FCLO also contains DHA and EPA, but in smaller quantities since the daily dosage is smaller.)

These fat-soluble vitamins are incredibly important to achieving clear skin. Did you know Retin-A and Accutane are actually forms of Vitamin A? That’s one reason why they can be so effective at clearing acne. Now, they’re extremely dangerous with lots of side effects, so I’d never recommend doing these treatments. But the Vitamin A you get from whole foods (like fermented cod liver oil, grass-fed liver, etc.) is quite safe in the context of adequate Vitamin D (I’ll get to that in a minute).

(As an aside for our veg-loving readers, vitamin A from animal sources, (retinol, e.g. from cod liver oil), is much more readily absorbed by the body than Vitamin A from vegetables (beta-carotene). Vitamin A from carrots, for example, is a lot more difficult for your body to work with, so even if you eat lots of carrots, you could still be deficient in retinol-based Vitamin A.)

FCLO is oil naturally extracted from cod livers using a natural fermentation process, which – according to supplement company Green Pasture – helps to preserve these precious fat-soluble vitamins better than other methods involving heat.

The only company I know of that makes FCLO, currently, is Green Pasture.

We take the cinnamon tingle flavor – it’s pretty a-ok, actually – at 2 mL per day. If you’re really not up for tasting the stuff, you can buy it in capsule form, but you end up paying a lot more (you have to take about 4 capsules per day).  I’ve heard the chocolate gel is disgusting, but if anyone out there has actually tried it, let us know how you liked the taste.

You could also take their “fermented cod liver oil + butter oil blend,” which includes high-vitamin butter oil for an extra-big dose of the super-rare Vitamin K2, in a very biologically available form. However, if you suspect you might be dairy-sensitive, which many acne sufferers are, the straight FCLO is probably a better choice.

You can buy the FCLO directly from Green Pastures – shipping’s not free, but it’s the cheapest way at the time of this writing. (If you prefer to buy from Amazon, you can do that here.)

Important note if you take fermented cod liver oil

It’s important that you take Vitamin D as well, since it protects against Vitamin A toxicity. Cod liver oil has large amounts of Vitamin A, which are perfectly safe if you’re getting adequate Vitamin D, but can lead to Vitamin A toxicity if you’re deficient in Vitamin D.

See our Vitamin D article for dose recommendations.

Key Takeaways

  • Do NOT take regular fish oil, period. It’s often rancid and increases lipid peroxidation in the body (BAD).
  • Cod liver oil, however, especially fermented cod liver oil, can help acne by providing essential fat-soluble vitamins (A & D).
  • Cod liver oil is not a complete treatment for acne, because it doesn’t fix the root causes of acne.
  • Cod liver oil can be a helpful addition to a holistic diet- and lifestyle-based treatment for acne.
  • You need to fix your diet and lifestyle to really cure the root causes of acne (that’s what our book is all about!).

While cod liver oil can give you a great boost in skin-healthy fat-soluble vitamins, there’s even more you can do to kickstart your journey to clear skin.

If you’d like to be walked through the whole process of tweaking your diet for clear skin, we (Devin and Sonia) have written an e-book that does just that. It’s called Clear Skin Forever (a very original name, right?).

For this complete guide to taking an all-natural, diet-based approach to getting rid of acne and having clear skin for life (no kidding!), go here.

Sources (click to expand)

  1. Inflammation. Wikipedia ^
  2. Masterjohn, Chris. Precious Yet Perilous. The Weston A. Price Foundation, 2010. ^
  3. Masterjohn, Chris. Precious Yet Perilous. The Weston A. Price Foundation, 2010. ^
  4. Freeman MP. Omega-3 fatty acids in major depressive disorder. J Clin Psychiatry. 2009;70 Suppl 5:7-11. Review. ^
  5. 44 Conklin SM, Manuck SB, Yao JK, Flory JD, Hibbeln JR, Muldoon MF. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom Med. 2007 Dec;69(9):932-4. Epub 2007 Nov 8. ^
  6. Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi L. Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest. 2005 Nov;35(11):691-9. ^
  7. Safarinejad MR, Hosseini SY, Dadkhah F, Asgari MA. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. Clin Nutr. 2010 Feb;29(1):100-5. Epub 2009 Aug 8. ^
  8. Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord. 1997 Aug;21(8):637-43. ^
  9. Chambrier C, Bastard JP, Rieusset J, Chevillotte E, Bonnefont-Rousselot D, Therond P, Hainque B, Riou JP, Laville M, Vidal H. Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma. Obes Res. 2002 Jun;10(6):518-25. ^


  1. Scott says


    I’ve read your articles on Vitamin A, Vitamin D, Zinc, and this Cod liver oil. And these are all things that I want to try. Would you recommend taking them at the same time? Or should I try them one by one?

    These are all things I think I lack in my diet. I get lot of Vitamin A from Carrots, but not the really good kind you talked about from liver so I am definitely going to get that Cod Liver Oil (not the one with the butter oil since I think dairy might trigger some of my acne). On average, there are 3-5 days in a week where I am embarrassed to admit that I probably don’t get any sunlight, so getting a Vitamin D supplement sounds like a good idea. I maybe eat one (maybe 2) pieces of meat a day (mostly chicken breast), so Zinc sounds good too.

    • Devin Mooers says

      Hey Scott! Up to you. There’s the shotgun approach – try everything at once in the hopes that something will work, and figure out what the most effective things are later (by removing changes/supplements). That’s generally what I’ve done in the past, since I always just wanted to get clear skin as fast as possible. Other people prefer to do a one-at-a-time approach. That really can give you better data about what was actually working. I’d much rather have fast results over better data, and figure out the data later if necessary.

  2. Nina says


    I was hoping you could advise me on how much vitamin K2 and D3 should be taken in conjunction with Green Fields FCLO butter blend to help against vitamin A toxicity?

    • Devin Mooers says

      Hey Nina! So FCLO contains vitamin D, so it may help protect against A toxicity. And the butter oil contains K2. It’s pretty unlikely, in my estimation, that you’d get A toxicity from taking the FCLO/butter oil blend. If you’re really worried about that, you could take Life Extension Super K and also supplement with D3, but I’d get your D levels tested to make sure you’re not going too much over ~35 ng/mL (a good target according to Chris Kresser). Does this answer your question?

  3. Laura says

    You lose a lot of credibility the moment you cite “Wikipedia” as one of your references…just say’n. There is some validity in what you say, but fish oil shouldn’t be condemned, there are health benefits in the supplements that people who don’t normally eat (or have access to) fish can get. Also, not everyone loves the taste of cod liver oil…

    • Devin Mooers says

      Hey Laura! I know Wikipedia used to be pretty sheisty, but these days, for a lot of medically-related articles, it seems to be pretty well-put-together and well-edited. That particular Inflammation article cites 97 different sources, most of them studies. Especially for definition-related things (i.e. “what is inflammation”), I think Wikipedia does pretty well. We try to go straight through the studies for citing hard data, though, as there’s the potential for misinterpretation.

      We’re also not totally condemning fish oil – there are definitely health benefits if someone doesn’t have another good source of omega-3’s! – we just don’t think it’s an optimal supplement compared to, say, FCLO. I agree that it doesn’t taste fantastic, but there are several flavors from which to choose, admittedly none of them delicious by any means, but workable for a lot of people, it seems. And fish oil just isn’t optimal For the stated omega-3/6-overload reasons, and the fact that you’re not getting vitamin A+D along with (like FCLO). Chris Masterjohn is on the forefront of fatty acid research, and I think a lot of people would regard his conclusions/research with heavy skepticism (as they’re right to). We just think he’s on to some difficult/nuanced questions that no one else is really asking.

  4. Tina says

    Do you have any info on how Salmon Oil works with acne? I have moderate adult/hormonal acne and cannot seem to get rid of closed pores and redness. I just brought Salmon Oil from Trader Joes, but after reading this blog – I’m much more hesitant. Thanks!

    • Sonia Carlson says

      Hey Tina – salmon oil is a type of fish oil, so everything we write about fish oils in this article applies to that as well. If you want to give your bottle of salmon oil a try, go for it – it’s long-term use of fish oils that seems to be really problematic. However, once the bottle’s gone, I suggest trying a bottle of Green Pasture fermented cod liver oil, for all the reasons mentioned above!

  5. Mindy says

    Hi there,
    I appreciate your guys’ blog and ebook! I am currently trying to pursue a natural approach towards treating my mild, but persistent acne. I had a question about the cod liver oil. At my local Wholefoods Store they offer cod liver oil (the brand is Nordic Naturals). However, it’s not fermented. As long as I take a Vitamin D3 (5000 IU) supplement should it still be nearly as effective? Are there any cons in taking this instead of fermented? My husband and I are on a budget…so I was hoping to try the Nordic Naturals since it’s a bit cheaper…but don’t want to take it if it would not be good for my body/acne.


    • Sonia Carlson says

      Hey Mindy! You and Vincent (the comment below) have basically the same question, so check out the response I just wrote to him. Here’s some specifics about Nordic Naturals, copied from the article I linked below:

      “The third type is the fully cleaned and deodorized cod liver oil with synthetic vitamins added back in. Most of the cod liver oils on the market fall into this category… These vary in dose from about 1100 to 4600 IU vitamin A per teaspoon and 180 to 460 IU vitamin D per teaspoon. One company, Nordic Naturals, now adds supplemental vitamin D to their Nordic Naturals Vitamin D brand, to compensate for the vitamin D removed during processing.”

      So the con is that there are far fewer natural nutrients in the Nordic Naturals variety – they add synthetics to make up for it. It’s not that it would necessarily be worse than not taking any at all… just not nearly as nutrient-dense and -diverse, probably, as the fermented kind we recommend.

      I know it kind of sucks that the best-for-you stuff is often more expensive, but this is one case in which I think you get what you pay for.

  6. Vincent says


    So I was wondering about the double strength Now Foods Cod Liver Oil supplement. It has both vitamins A & D, but apparently some of the vitamin A comes not only from the Cod Liver Oil but also from Retinyl Palmitate. I have been taking 10000 iu’s worth everyday, but I’m thinking twice about it now that I read your article on Vitamin A (getting it from all natural sources). Is this safe to take? I initially didn’t want to buy the FCLO blend because I had heard bad things from other sites about the fermentation. They were saying there was no reason to be eating rotting fish oil when you could have it fresh, and some people had had terribly adverse effects.
    Also how much K2 does one need for 10000iu of Vit A?

    • Sonia Carlson says

      Hi Vincent! Good questions. So first, fermentation is not a negative when it comes to cod liver oil; in fact, it’s a huge positive. I’ll refer you to this article about how cod liver oil processing. It’s dense, so I’ll give you the gist here: most commercial cod liver oils are subjected to alkali refining, bleaching, winterization, and/or deodorization. Each of these processes affects the nutrient quality of the resulting CLO very significantly – so much so that many brands actually add back synthetic vitamins A & D (it sounds like your brand is one of these) to make up for processing the natural ones out! The fermented cod liver oil we recommend is processed entirely naturally, through fermentation, and therefore preserves the maximum amount of precious nutrients.

      K2 – Chris Kresser recommends about 100 mcg of K2 per day (along with 10,000-15,000 IU FCLO).

      Hope that helps!

  7. John Anderson says

    I have what seems to me like mild to moderate acne and have noticed that many people have mentioned that omega 3 fish oil improves their acne. So I decided to go out and buy it myself, and my acne has not gotten better but in fact, ive gotten more acne each day that had passed, but I dont know whether its the fish oil or not. I normally do have oily skin but its just bugging me and id like to know what your thoughts were on this.

    • Sonia Carlson says

      Hey John, it’s true that many people do experience an improvement in their acne if they take fish oil, but that is more of a cover-up than a curative measure. Our opinion is that rather than drowning yourself in omega-3s, it’s best to reduce your omega-6 intake and get a moderate amount of omega-3s (naturally from the diet, ideally). Especially since you’ve had a worsening of your acne since taking the fish oil, I’d say it’s a good idea to stop taking it. Focus instead on reducing your intake of vegetable oils/polyunsaturated fats, and you’ll get much of the same benefit of fish oil without the extra fragile fatty acids.

    • Sonia Carlson says

      Hi Lisa, great question. It is possible that the very small amount of dairy hormones in the butter oil portion of the FCLO-butter oil blend could trigger acne in an extremely sensitive person. The high-vitamin butter oil component contains K2, an important vitamin that many people are lacking. However, if you’re at all concerned that you might be sensitive to the dairy, just take straight FCLO.

  8. Andre says

    I’m gonna get this fermented cod liver oil off Ebay, it’s $44 but i don’t care i wanna have a clear face again. I’m sure it’s worth a try.

    • Sonia Carlson says

      Haha, yep, it ain’t cheap… but we think it’s worth it for the health/acne benefits. And if you consider this in relation to how much most other acne treatments cost, the price doesn’t seem quite so steep!

      • Andre says

        I have a big question, should i go ahead and buy this stuff even though i have already bought Clearazene off Ebay just yesterday. Or should i first try out the Clearazene and if it doesn’t work to just buy the liver oil.?

        • Sonia Carlson says

          Clearazene is an herbal approach to treating acne, while fermented cod liver oil comes at acne from a whole other angle – providing vital, fat-soluble vitamins that are lacking in many people’s diets. As to what you should do, it’s up to you! If you think both have the potential to help you, take both for quickest results. If you really want to know what works and what doesn’t, try one for a month, then try the other for a month, and see which seems to work better. If you do this, be aware of the possibility of a carry-over effect on your skin in the second month that’s caused by what you took in the first month.

          Of course, I want to mention that all the liver-supporting herbs you can get (which, there are some in Clearazene) aren’t going to do a bit of good long-term if you have a diet and/or lifestyle that continues to tax the liver. Which is to say, no supplement is in itself likely to be a cure – we see them more as a crutch that can help ease your body’s transition to a healthier way of eating and living.

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