Fish Oil vs. Cod Liver Oil for Acne: A New Perspective

Sonia taking fermented cod liver oil for clear skin

Sonia demonstrates the joys of taking fermented cod liver oil for clear skin!

What do fish oil and cod liver oil have to do with acne, anyway?

In a nutshell, fish oil – or rather, omega-3 fatty acids – appears to help some people clear up their skin faster.  This is because omega-3s reduce inflammation in a few different ways.

Sounds good, right?

Inflammation is a major contributor to acne, so it’s tempting to think it’s a good idea to start taking fish oil.

But before you go running to the store or your favorite retail website for a bottle, let me say this: although we used to recommend supplementing with fish oil, we advise against it now.

In fact, taking fish oil may ultimately make your acne worse.

First, I’ll tell you how fish oil “works.”

Fish oil contains a large amount of omega-3 fatty acids, particularly EPA and DHA, which interact with omega-6 fatty acids to reduce or end your body’s inflammatory response.

When you have a really skewed omega-3:6 ratio in your diet – as in, way too much omega-6 and not enough omega-3 – your inflammation levels skyrocket.

Not good!

And for some years now, people have been using large doses of fish oil to treat inflammation by balancing out those pesky omega-6s.

How does inflammation relate to acne? Well, It’s responsible for the redness and swelling that makes acne so embarrassing. Reduce inflammation, and your acne won’t swell up so much (or get so cherry-red).

Cod liver oil, on the other hand, works to heal acne mainly because it gives you a big boost of vitamins A and D, both of which are critical, acne-curing vitamins. While it also contains some omega-3s, the dosage is far smaller than what you’d get in a dose of fish oil. We do recommend taking fermented cod liver oil, which I’ll explain more later on.

Okay… so what are fish oil and cod liver oil, exactly?

Fish oil is basically oil that’s extracted from fish bodies, while cod liver oil is taken from the livers of codfish. Pretty simple.

And like I said above, fish oil is a powerful source of omega-3s, and omega-3s have anti-inflammatory effects.

What’s the big deal with inflammation?

You see, these days, most of the common Western diet is highly inflammatory.

What does that mean, exactly?

Well, it means that most people are eating way too many foods loaded with omega-6 fats, sugar, trans fats, and gluten, all of which are pro-inflammatory.

These inflammatory foods drive your immune system to do insane things, like causing swelling where you least want it – arthritis, for example, and of course, acne.

When your immune system is on constant red alert, and it stumbles across a clogged pore on that lovely face of yours, it dives in for the attack! The clogged pore becomes inflamed, red, and swollen, leading to nasty-looking zit-monsters.

You see, if your immune system were healthy and normal, a clogged pore wouldn’t cause a big fuss. Your body would heal the ruptured pore pretty quickly and then go on functioning normally. No big deal! But when your body is in a constant state of hyper-immune-activation and inflammation, any little thing sets off your immune system – and that leads to disastrous consequences for your face.[1]

How do omega-3s affect inflammation?

Before I get to that, let me explain a few things about the essential fatty acids: omega-3s and omega-6s. While there are many different fatty acids in the omega-3 and omega-6 families, only a couple are actually really useful and needed in the body. These are docosahexaenoic acid (DHA), an omega-3, and arachidonic acid (AA), an omega-6.

Arachidonic acid is critical to the initiation of an inflammatory response, which is why it gets a bad rap. However, AA also turns on the cellular machinery that activates DHA, which helps to bring that inflammatory response to an end.

Together, these two fatty acids are a part of an intricate chemical dance in the body that starts an inflammatory response when it’s needed and then stops it when it isn’t needed anymore.

(Another omega-3 found in fish and fish oils, eicosapentaenoic acid, or EPA,  reduces inflammation mostly by interfering with AA… and therefore with the whole process of inflammation and its resolution. It can actually depress growth and immune function, which is why we’re not too excited about EPA.)[2]

As you can see, omega-3 fats – namely DHA – have an incredibly powerful role in quickly resolving inflammation when it is no longer needed.

The key here is your ratio of these omega-3s to pro-inflammatory omega-6 fats. The rub is that if the inflammation-initiating omega-6 fats aren’t balanced by sufficient omega-3s, your immune system goes vigilante on you (boom! Faceful of acne).

Now, if you were eating like a hunter-gatherer of yesteryear – e.g. wild game, tubers, nuts, vegetables, the odd beehive – you’d have an omega-3 to omega-6 ratio of around 1:1 (ideal, by some estimates).

But in this day and age, omega-6 fats are in everything – canola oil, safflower oil, vegetable oil, corn, soy, wheat – basically most of the JFBBs (Junk Food Building Blocks) in today’s fast-food world. Most cookies, crackers, snacks, breakfast cereals, and granola bars are made primarily with these JFBBs, which, again, are highly inflammatory.

That’s bad news for acne!

In short, you’ve got to optimize your omega-3 to -6 ratio if you want clear skin.

This will help quiet your immune system down, taking it from red alert down to orange alert, yellow, maybe even just “Ready for action, we’re here when you need us!”

And that’s where you want it.

You want a perfectly functioning immune system that shoots into action when there’s a real problem in your body, not when you get a stinkin’ little clogged pore. And you want an immune system that quiets the heck down when the problem is solved, rather than sticking around for days, partying in your pores and creating red, swollen, painful acne. You’ve had enough of that, right?

So why shouldn’t I take fish oil?

The common wisdom goes like this: fish oil gives you a huge blast of omega-3s (EPA and DHA), which is good because it balances out your omega-6 intake, reducing inflammation.

That seems like a good idea on the surface.

However, I haven’t gotten to the nasty part yet: all omega-3 and omega-6 fatty acids are highly reactive in the body.

Why? Well, they’re polyunsaturated fats (PUFAs). In chem-speak, they contain two or more double bonds, which makes them billions of times more reactive than, say, saturated fat (grass-fed animal fat, coconut oil, red palm oil, etc.). And millions of times more reactive than monounsaturated fat (olive oil, avocados, etc).

Why is this potentially dangerous?

Health researcher Chris Masterjohn came up with a really apt metaphor for PUFAs – he compares them “delicate glass.”

Now, glass is incredibly useful in our modern world (can you imagine windows made from steel?). But glass is also extremely delicate – it shatters easily, fragmenting into a million pieces that spread far and wide across the floor, can cause all kinds of bodily harm, and can take a long time to clean up.

PUFAs are very similar. Like glass, they’re very useful for the body for some critical bodily functions, but they’re extremely delicate. When they “shatter” – i.e., when they get oxidized by a free radical – they set off chain reactions that oxidize other PUFAs, which oxidize still more PUFAs, which oxidize yet more PUFAs – it’s a gigantic, damaging ripple effect.

Worst part? These oxidized PUFAs (known as lipid peroxides) eventually break down into dangerous compounds like malondialdehyde (MDA), which can directly damage DNA and proteins throughout the body.

Oxidative stress like this can damage just about every biological tissue in the body, and – yep, you guessed it – can worsen acne as well.

Wolfing down a bunch of fish oil might reduce inflammation / redness / swelling in the short term, but can create a potentially worse long-term problem of oxidative stress.

(And if you need any additional convincing, consider this: in the longest and one of the largest fish oil trials ever conducted, the heart disease patients taking fish oil had a 30% increase in heart-related death!)[3]

Okay, so what should I do instead?

Better solution?

  1. Focus on getting your omega-6 intake as low as possible.
  2. Slightly increase your omega-3 intake using fermented cod liver oil.

Let’s go over these separately.

How to reduce your omega-6 intake

The main sources of omega-6 are:

  • Sunflower oil
  • Safflower oil
  • Peanut/groundnut oil
  • Cottonseed oil
  • Soybean oil
  • Corn oil
  • Grapeseed oil
  • Canola oil
  • Deep fried foods (which contain large amounts of the above oils)
  • Processed foods (which contain large amounts of the above oils)
  • Walnut oil
  • Flax oil

Here’s a more in-depth list of the omega-6 content of foods from 180 Degree Health: Omega-6 content in common foods.

And if you’re not convinced already, here’s a roundup of the key clear-skin benefits to improving your omega-3 to omega-6 ratio (by reducing omega-6 consumption):

Improving this fatty acid ratio can help…

  • Reduce redness and puffiness of acne lesions.
  • Moisturize your skin naturally, making your skin softer.
  • Reduce stress, preventing excess acne-causing sebum production.
  • Slow down skin cell over-production, keeping your pores open and free.
  • Balance hormone production, making your skin less oily.

In addition to helping clear your skin, a healthier omega-3 to -6 ratio can also provide the following benefits:

  • Reduced joint pain.
  • Improved mood. [4]  [5]
  • Improved brain performance. [6]
  • Stronger hair.
  • More energy.
  • Improved cholesterol levels.
  • Enhanced male fertility. [7]
  • Fat loss. [8]  [9]

That’s a key theme in this blog – by targeting the root causes of acne, you’ll also become healthier, fitter, and more radiant. You’ll be giving your body clean, high-octane food that’s loaded with essential nutrients that perform millions of complex, tiny functions in the body and lead to an awesome, healthy, clear you.

Why you should take fermented cod liver oil (FCLO)

There’s an exception to the “no fish oil” guideline – fermented cod liver oil.


Well, as I indicated above, it’s an incredible source of fat-soluble vitamins like A and D.

Pre-formed vitamin A especially is pretty difficult to get unless you’re regularly eating organ meats (e.g. liver), shellfish, large quantities of egg yolks, and butter. (FCLO also contains DHA and EPA, but in smaller quantities since the daily dosage is smaller.)

These fat-soluble vitamins are incredibly important to achieving clear skin. Did you know Retin-A and Accutane are actually forms of Vitamin A? That’s one reason why they can be so effective at clearing acne. Now, they’re extremely dangerous with lots of side effects, so I’d never recommend doing these treatments. But the Vitamin A you get from whole foods (like fermented cod liver oil, grass-fed liver, etc.) is quite safe in the context of adequate Vitamin D (I’ll get to that in a minute).

(As an aside for our veg-loving readers, vitamin A from animal sources, (retinol, e.g. from cod liver oil), is much more readily absorbed by the body than Vitamin A from vegetables (beta-carotene). Vitamin A from carrots, for example, is a lot more difficult for your body to work with, so even if you eat lots of carrots, you could still be deficient in retinol-based Vitamin A.)

FCLO is oil naturally extracted from cod livers using a natural fermentation process, which – according to supplement company Green Pasture – helps to preserve these precious fat-soluble vitamins better than other methods involving heat.

The only company I know of that makes FCLO, currently, is Green Pasture.

We take the cinnamon tingle flavor – it’s pretty a-ok, actually – at 2 mL per day. If you’re really not up for tasting the stuff, you can buy it in capsule form, but you end up paying a lot more (you have to take about 4 capsules per day).  I’ve heard the chocolate gel is disgusting, but if anyone out there has actually tried it, let us know how you liked the taste.

You could also take their “fermented cod liver oil + butter oil blend,” which includes high-vitamin butter oil for an extra-big dose of the super-rare Vitamin K2, in a very biologically available form. However, if you suspect you might be dairy-sensitive, which many acne sufferers are, the straight FCLO is probably a better choice.

You can buy the FCLO from this site – shipping’s not free (unless you spend $99), but it’s the cheapest way we know of at the time of this writing. (If you prefer to buy from Amazon, you can do that here, though it’s usually more expensive.)

Important note if you take fermented cod liver oil

It’s important that you take Vitamin D as well, since it protects against Vitamin A toxicity. Cod liver oil has large amounts of Vitamin A, which are perfectly safe if you’re getting adequate Vitamin D, but can lead to Vitamin A toxicity if you’re deficient in Vitamin D.

See our Vitamin D article for dose recommendations.

Key Takeaways

  • Do NOT take regular fish oil, period. It’s often rancid and increases lipid peroxidation in the body (BAD).
  • Cod liver oil, however, especially fermented cod liver oil, can help acne by providing essential fat-soluble vitamins (A & D).
  • Cod liver oil is not a complete treatment for acne, because it doesn’t fix the root causes of acne.
  • Cod liver oil can be a helpful addition to a holistic diet- and lifestyle-based treatment for acne.
  • You need to fix your diet and lifestyle to really cure the root causes of acne (that’s what our book is all about!).

While cod liver oil can give you a great boost in skin-healthy fat-soluble vitamins, there’s even more you can do to kickstart your journey to clear skin.

If you’d like to be walked through the whole process of tweaking your diet for clear skin, we (Devin and Sonia) have written an e-book that does just that. It’s called Clear Skin Forever (a very original name, right?).

For this complete guide to taking an all-natural, diet-based approach to getting rid of acne and having clear skin for life (no kidding!), get instant access here.

Sources (click to expand)

  1. Inflammation. Wikipedia ^
  2. Masterjohn, Chris. Precious Yet Perilous. The Weston A. Price Foundation, 2010. ^
  3. Masterjohn, Chris. Precious Yet Perilous. The Weston A. Price Foundation, 2010. ^
  4. Freeman MP. Omega-3 fatty acids in major depressive disorder. J Clin Psychiatry. 2009;70 Suppl 5:7-11. Review. ^
  5. 44 Conklin SM, Manuck SB, Yao JK, Flory JD, Hibbeln JR, Muldoon MF. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom Med. 2007 Dec;69(9):932-4. Epub 2007 Nov 8. ^
  6. Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi L. Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest. 2005 Nov;35(11):691-9. ^
  7. Safarinejad MR, Hosseini SY, Dadkhah F, Asgari MA. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. Clin Nutr. 2010 Feb;29(1):100-5. Epub 2009 Aug 8. ^
  8. Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord. 1997 Aug;21(8):637-43. ^
  9. Chambrier C, Bastard JP, Rieusset J, Chevillotte E, Bonnefont-Rousselot D, Therond P, Hainque B, Riou JP, Laville M, Vidal H. Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma. Obes Res. 2002 Jun;10(6):518-25. ^


  1. Amrit says

    Hi there , I have been taking CLO (green pastures) for a month now and its been helping my skin a lot! But since it has vitamin D in it , do I still need to take additional vitamin D ? I have been taking a tablespoon each day . So every 24 hours.

    Thank you!

    • Sonia Carlson says

      Hi Amrit, I’m really glad to hear that the FCLO is helping your skin!! I’m concerned that you’re taking a tablespoon each day – I would definitely back that off to 1 teaspoon at the most; 2 mL is actually what we recommend as a daily dosage over the long-term (which is about 1/2 tsp).

      You’re right that the FCLO contains vitamin D, but the quantity of D (and of D3 specifically) in FCLO can vary. I’ve read estimates that total vitamin D content is about 1000 IU per 2 mL. Whether you should take an additional vitamin D supplement depends. Do you get outside and get sun exposure directly on unprotected skin most days? If so, then you probably don’t need an extra D supplement. If you don’t, then you might consider supplementing D3 at 2000 – 5000 IU per day.

  2. hayley gray says

    Hi! So from the age 16-19 or 20 i used proactiv bc i thought i had ‘acne’ boy was i wrong. My skin was perfect the younger i was, as i’ve gotten older i’ve rly been hit with it. About a year ago, i tried the Clinique Kit and it cleared even the smallest of bumps i had here n there right up, my skin was perfect. I never had a single bump like i used to get, from time to time.. After 3 weeks of using Clinique my skin went crazy. I honestly woke up n it was worse n worse each day i woke up. I returned the product, went back to using Cetaphil cleanser, n it just kept getting worse. PArts of my face that nvr broke out like my forehead n cheeks, were terrible. I finally went to a dermatologist who prescribed me antibiotics. That healed me up over the course of 3-4 months n i stayed on them for 6-7 months bc it helped my acne. It cleared up what had spread all over my face but i still got little ones on my chin and jaw, and after my skin breaking out so severly to where it hurt to smile or move my mouth or raise my forehead, it left a lot of bad scarring n red marks. Ok so fast forward i quit cold turkey on antiobitocs bc they’re not good for long term use, n i researched natural products for acne. Manuka honey, witch hazel, tea tree oil, indian aztec healing clay bentonite, apple cider vinegar. I made a toner w/ that, i did clay masks, honey for the redness which i do believe that helped a good amount, but my skin is still off n on w/ alot of scarring n red marks, i’m still getting cystic bumps so i am trying this 30 day no wash but water every other day regimen. I’m trying to get my skins Ph level normal again without the use of any products or over washing w/ the acception of just water when i shower. Will fish oil supplements or cod liver oil supplements help w/ the cystic acne? The pain of cystic acne or scarring? Or do u have any advice for me? I’m a pretty healthy person, not as healthy as i used to be but mostly i am, i do consume dairy, i’m not on any special diets either n i don’t take any sort of supplements now, i’ve been off antibiotics since august 10th of this yr. thank u!!!!!

    • Sonia Carlson says

      Hi Haley! Whew, what a story… what a turnaround! Good for you for going all-natural. My best suggestion for you is not to take a fish oil / cod liver oil supplement, but to eat liver. Yep, eat 1/4 pound of liver (chicken, beef, lamb, goat, whatever) per week – it’s packed with vitamin A and loads of other skin-essential nutrients. If that’s simply not something you can do (though I encourage you to try it once, starting with chicken livers), then try fermented cod liver oil, 2 mL per day. Green Pastures is the brand we recommend, links and other info in the blog post above. My second suggestion to you is to stay away from the antibiotics from now on, and start taking care of your gut – read this article on antibiotics, your gut, probiotics, and fermented foods. Good luck to you!!

Like what you read? Have something to share? Leave a comment below! Your ideas are much appreciated, though we can't answer every individual question. :)

- Devin and Sonia

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